Gregory Wiles is the son of Paul Wiles and Cynthia Wiles. A vengeful Brian Dempsey, angry because he had been fired from his job by Paul, designed a computer virus that was capable of liquefying a person's brain when observed by a person. As part of an elaborate revenge scheme, he sent the virus to Wiles' son Gregory, who unsuspectingly opened the video after having a short conversation with his friend.
Gregory became focused on the strange video, which eventually caused him to hallucinate that his computer screen was morphing into an arm that was reaching out to grab him. Gregory subsequently died, and was later found by his parents. His body was delivered to Walter Bishop, who along with Peter Bishop, performed an autopsy, in which they discovered that his brains had been completely liquefied. ("The No-Brainer")